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  • Associate Professor and Assistant Director of Clinical Affairs, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado
  • Associate Professor, Department of Family Medicine, University of Colorado School of Medicine, Aurora, Colorado

Program Consultants assist students in selecting an appropriate research project and preceptor symptoms of hiv cheap 200 mg sustiva with amex. In addition to xerogenic medications generic sustiva 200mg online working on his/her own research project hair treatment purchase sustiva 600mg overnight delivery, each student views web-cast seminars addressing clinical and research aspects of diabetes mellitus and its complications treatment research institute buy sustiva 600mg line. Students spend 2-3 months working on their research project at a Diabetes Center and receive a weekly stipend. Mounting Evidence: the Third Dimension Matters · Alterations of genome organization are associated with laminopathies, cancer and premature aging syndromes; · Features are often cell- or tissue-specific, and include: - loss of genome integrity; - global changes in epigenetic marks; - widespread modifications of gene expression programs. Mounting Evidence: the Third Dimension Matters · 93% of disease-associated genetic variants reside in non-coding regulatory sequences with unknown targets; · Mapping physical interactions between regulatory variants and promoters would help identify disease-associated target genes; Mounting Evidence: the Third Dimension Matters · Chromosome Conformation Capture (3C) allows mapping of long-range looping interactions between genes and regulatory elements. A network of small research consortia, each focused on a specific biological challenge. Develop tools and ontologies for data annotation and to facilitate analyses across data types. New (often small) cores can be appropriate, yet they can be judged harshly by the standards of fully established, mature cores. How do we stress the desirability of nimbleness and timeliness and the need to evaluate different kinds of cores (established, new) by different criteria? Publications are linked to specific cores and the Pilot & Feasibility Programs in renewal applications. Health Policy: Mexico has recently imposed a sugar or soda tax (10%) on soft drinks and an 8% tax on junk foods in an attempt to address their obesity epidemic. They recognize major initiatives are required or their health care costs will explode. This has potential to improve the science and facilitate ability of next generation of scientists to leverage big data. But faculty and trainees with strong biology background may have insufficient training in mathematical, statistical, or programming approaches to effectively mine large data sets in customized way. For computational biologists most interested in discovery of mathematical and computational underpinnings of analysis algorithms that can facilitate design and evaluation of new approaches, simple scripting to reformat files and extract data from databases may not have appeal. Co-mentored F/K series trainee and their program could serve to integrate the biological and computational approaches, mentors in different fields will have motivation for mentoring in own area of work for which funding exists. Activities raising awareness and interest in diabetes research and clinical care at center institutions, locally, regionally, and nationally: · Center website developments · Diabetes Research Center-sponsored seminars & symposia (only those sponsored by or supported with Diabetes Center funds) · Regional and national presentations (list all that were sponsored by or supported with Diabetes Center funds; i. Activities enhancing diabetes education and training opportunities for patients, students, scientists and clinicians: · Enumerated changes in related Ts, F & K awards · Joint activities (training, symposia, etc. Significant changes from previous year · New personnel · New services or changes in existing services (Table or Text) B. Solicitation · Number of new (or continuing) P&F applications reviewed (may also include number of letters of intent received, if applicable) · Types of applications reviewed o new invest, established investigator new to field, innovative partnership o basic, clinical, phase I translation, prevention & control o diabetes, endo, obesity, autoimmunity, transplantation o inter or trans-disciplinary · Review process (only if altered from previous years) (Table or Text) B. Describe progress along a translational continuum in your center for a selected topic area/project. All Personnel Report External Advisory Report: If your Center has a report from an External Advisory meeting during the past year, please include a copy in your annual progress report. By adding to this Table each year in the progress report, you should have less work for the renewal application. Individual Components for Center grants include: Administrative Core, Biomedical Research Cores, P&F Program(s), and Enrichment Program 7. Report the major goals specific to an individual component under that component/core. This can be a retrospective analysis, or an example of a current project or area that is actively progressing along the translational continuum. If the Revision/Supplement is associated with a specific project or core, identify the component. If your Diabetes Center received supplemental funds in the past 1-3 years, please be sure to include an update on progress made with these funds. If there are individual projects/cores designed to disseminate information or conduct outreach activities, report those activities under that component.

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If the material is for study only treatment brown recluse spider bite best 600 mg sustiva, it may the conservation of archaeological leather 255 Figure 22 symptoms zinc toxicity discount sustiva 200 mg overnight delivery. As a further refinement symptoms mercury poisoning buy discount sustiva 200mg line, the type of tannin may be identified by the application of a drop of vanillin in alcohol medications and side effects discount 600 mg sustiva, followed by a drop of concentrated hydrochloric acid. It should be noted that the test results will not show on very dark leathers, and that a positive result demonstrates the presence of tannins, not necessarily tannage. Testing a cross-section of leather is of greater value, showing whether the tannin is superficial. If so, it may relate to a vegetable colouring agent such as pomegranate juice or madder. Care is required with very decayed material, as water may rapidly convert aged skin to gelatine, or, with acidic leather, activate residual sulphates to create sulphuric acid. Tannin tests carried out on some early medieval Nubian (Welsby, 1998) leather samples in the British Museum (Thickett and Wills, 1996) showed varying results. Extracts were tested separately with ammonium ferric sulphate solution for the presence of tannin, and aluminon (the triammonium salt of aurintricarboxylic acid) solution for the alum. Thin caprine leather gave some positive results for vegetable tan, and the thicker thongs (more likely to be raw hide or simply tanned) gave a range of results, including positive for the presence of alum. It should be noted that any possible background contamination with alum had not been taken into account, so these results should be interpreted with discretion. The presence or absence of a woolly winter coat may indicate the season of death (Ryder, 1987). The 256 Conservation of leather and related materials thickness of the leather is of interest, giving some indication of the species and age of the animal if intact, and leatherworking techniques if split. Seams stitched when wet are recognizable by distortion created by the pull of the thread. In examples of excavated Kerma leather, where no textile remained, the indentations of a plain-weave textile were evident. Weave analysis was possible; four pieces of leather revealed thread counts varying from 10 to 12 threads by 12 to 14 threads per 10 mm2 (Welsby, 2001). Temporary pliancy is, however, useful when reshaping a three-dimensional object (Wills, 2000), and such methods will be considered more fully below. Dye and pigment analysis techniques might be accessed and adapted from textile analysis protocols (Smith, 2000). Samples should of course be taken before treatments begin to safeguard the future potential for analysis. Desiccated leather is, however, occasionally found in such good condition that intervention is neither necessary nor desirable (Volken, 2001). Dressings lubricate working leather structures such as harness, but can be damaging to aged leather. Dry leather pieces treated with glycerine and thymol in the Louvre in the 1980s had, when re-examined, turned from red to black (Montembault, 2001). Leather dressings damage in the following ways (Raphael, 1993): (a) (b) (c) (d) (e) (f) (g) (h) (i) darken many lighter colour leathers encourage mould and biological attack form fatty spews over the surface oxidize over time to stiffen the material wick into surrounding materials soften original finishes and decoration cause dust to accumulate impede future conservation treatments contaminate the material for future scientific analysis to which may be added: (j) provide a route of ingress for contaminants and catalysts for further decay. The standard range of non-aqueous cleaning treatments (dry brushing, vacuuming, Wishab sacrificial rubber, Consolidation is sometimes necessary to strengthen a fragile object in situ on site. It allows lifting and subsequent safe transport, handling, recording and reconstruction of an item that might otherwise be lost or damaged. If first-aid consolidation is required, it becomes particularly important to remember to take samples for analysis before treatment. Conservation standards require such a material to confer resilience, strength, stability, flexibility, reversibility, and retain colour and surface qualities. Resins currently or recently used in dry leather consolidation include those based on acrylic resins such as Paraloid B72, Paraloid F10, Pliantex; those based on cellulose such as Cellugel, Klucel G, and others such as a polyvinyl butyryl (Mowital B30H). A wider range of potential consolidants has been explored in the past, including gelatine, polyurethanes, polyvinyl acetate emulsions, epoxy resins and a polyvinyl acetate/ethylene copolymer (Vinamul 3252). Though many of the above resins are useful in specific areas, new materials are still sought for conservation treatments in the studio and on excavation. Cyclododecan (Jagers and Hangleitner, 1995; Hilby, 1997), a temporary consolidant of fragile material, is worth investigation for use on site. Some conservators have found it beneficial to treat dry leather as wet; to rehydrate it and then treat as waterlogged (Volken, 2001).

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Additional objectives include technology demonstrations-for instance medicine etodolac order 200mg sustiva amex, tank material and manufacture 5 medications order sustiva 200 mg amex, reaction control thrusters treatment 1st metatarsal fracture buy sustiva 600mg lowest price, main engine performance improvements treatment urinary retention generic 200mg sustiva with visa, helium pressurization systems, ground operations, flight operations, range safety, software, and avionics architecture. Morpheus is a full spacecraft, with all the associated subsystems: avionics; software; guidance, navigation and control; power; power distribution; structures; propulsion; and instrumentation. It can be stored for longer times in space, compared to other common propellants such as liquid hydrogen. It is extremely cheap and safe to operate and test, and performs better-much more so than hypergols, another type of fuel often used in space flight. In fact, about 454 kg (1000 lbs) of methane are produced on International Space Station and dumped overboard as waste gas every year-enough to entirely fill the Morpheus lander. In addition, the lander has all the systems required for automated rendezvous and docking. For an asteroid rendezvous, the lander would need more study, but conceptually the lander may have most of the systems needed to attempt an asteroid rendezvous. The precision landing system for Project Morpheus, with some modification to the software, could be used as is to rendezvous with an asteroid. The workforce behind Project Morpheus has gained valuable experience that will provide the cornerstone for design of future missions. In addition, the project is setting mid-range performance and design requirements that will drive down the production cost of future landers. Project Morpheus is taking the lessons learned from our industry partners to facilitate this alternative design approach. The first, Pixel, was literally constructed from spare parts from Armadillo Aerospace through an Innovative Partnership Agreement. Careful consideration has been given to the surroundings when planning thrust levels and future trajectories (figure 3). In addition, during a free flight, spotters are being placed in multiple locations to ensure that if the vehicle goes outside of the established flight path, the engine will be immediately shut down. The Vertical Test Bed Flight Complex has three different pads that will be used for Morpheus testing (figure 4). The single pad on the west end of the complex is used for both hot fire and tethered tests. During a free flight, Morpheus will fly up to a height of around 30 m (98 ft), then translate over to the western pad and descend for a soft landing. The tiny grains of wassonite were found in the Yamato 691 enstatite chondrite, a rare type of meteorite that originated in the asteroid belt and later fell to Earth in Antarctica. The team measured the chemical composition of the grains, but were unable to determine its other properties. The microscope analyses revealed the atomic structure of the grains, showing that wassonite has a relatively simple crystal structure consisting of alternating layers of titanium and sulphur atoms. Researchers measured the chemical composition of wassonite and the speciation of. Wassonite grain in the Yamato 691 meteorite: (a) bright field transmission electron microscope the constituent atoms using x-ray and image showing a wassonite grain in dark contrast; (b) high angle annular dark field transmission electron spectroscopies at nearly the electron microscope image of the same grain; (c) high-resolution transmission electron microscope atomic scale. Inset is the selected area electron diffraction between wassonite and the other pattern of wassonite. These data were sufficient for the Committee on oxygen and is referred to as a lithophile element. In New Mineral Names of the International Mineralogical wassonite, the titanium is bonded to sulfur, indicating Association to give official approval for the name that it formed in a strongly reducing (oxygen-poor) "wassonite. These studied by scientists for decades in the semiconductor conditions existed close to the sun in the early solar system industry, but it had never before been found in nature. The Hayabusa capsule is examined by the parachuted recovery team following reentry. The atmospheric reentry and landing of the spacecraft was flawless, and the capsule landed very near the center of the calculated landing ellipse-an astounding feat considering the difficulties in navigating the spacecraft and steering it into the atmosphere. Figure 1 shows the Hayabusa capsule, following reentry, under examination by the recovery team. The team was prepared to douse the spacecraft with spermicide liquid in the event the capsule had opened upon landing.

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From this screen symptoms xeroderma pigmentosum discount sustiva 600mg mastercard, the next reviewer can be chosen from a list of reviewers medicine vs surgery generic 200mg sustiva mastercard, and comments can be added medicine you cannot take with grapefruit buy cheap sustiva 600mg line. Optional: Enter comments in the Comments text box to medicine lake california cheap sustiva 600 mg with mastercard provide information to the next reviewer. This is useful in situations when the report was routed to the wrong person or the reviewer is unavailable. Deliberate withholding, falsification, or misrepresentation of information could result in administrative actions such as withdrawal of a progress report, suspension and/or termination of an award, debarment of individuals, as well as possible criminal penalties. The progress reports for incrementally-funded and multi-year funded awards are displayed differently in Other Relevant Documents. If unable to provide the verification of compliance, grantees can upload and submit justification for why specific publications cannot be brought into compliance. Enter the appropriate query parameters to locate the grant and select the Search button. Use the Upload Attachment pop-up Browse and Upload buttons to search for and attach the appropriate file. The table displays the Document Name and Action links of View and Delete for each attachment. The ability to upload and submit additional attachments remains until the grant is awarded. Information in the document can be navigated using the provided bookmarks on the left. Many of these instructions apply to other awards but there may be exceptions (items that are not applicable, replace, or are in addition) for awards not listed above. Refer to the table in chapter 7 Supplemental Instruction for Specific Grant Award Types and follow the appropriate instruction for the applicable activity code of other awards. Not Applicable next to a particular item indicates that item does not apply to the particular kind of award, and the item should be ignored. All other prior approval requests must be submitted directly to the Grants Management Officer of the awarding component in accord with the Grants Policy Statement, 8. The addresses, emails and phone numbers are pre-populated from the Commons Profile. To update contact information as displayed, go to the Commons Profile and save the changes there. To select a Signing Official and Administrative Official, choose a name from the associated drop-down box. It is not a mandatory field and the awarding agency will disregard the information. Accomplishments allows the agency to assess whether satisfactory progress has been made during the reporting period. If the application lists milestones/target dates for important activities or phases of the project, identify these dates and show actual completion dates or the percentage of completion. Also explain any significant changes in approach or methods from the agency approved application or plan. Significant changes in objectives and scope require prior approval of the agency. Select Yes if the major goals/specific aims have changed since the initial competing award or previous report, and provide a revised description of major goals/specific aims. Remember that written prior approval from the awarding agency grants official is required for significant changes in the project or its direction. For this reporting period describe: 1) major activities; 2) specific objectives; 3) significant results, including major findings, developments, or conclusions (both positive and negative); and 4) key outcomes or other achievements. As the project progresses, the emphasis in reporting in this section should shift from reporting activities to reporting accomplishments. In the response, emphasize the significance of the findings to the scientific field.

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