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Some articles contain additional topics beyond those in the template; in these cases muscle relaxant 563 pliva buy 60 caps shallaki with visa, the Oracle system produces a longer article than our algorithm back spasms x ray discount shallaki 60 caps without a prescription. Table 2 shows the average number of excerpts selected and sources used in articles created by our full model and each baseline muscle relaxant vs painkiller order 60 caps shallaki with amex. Automatic Evaluation To assess the quality of the resulting overview articles spasms left upper abdomen shallaki 60 caps for sale, we compare them with the original human-authored articles. Analysis of Human Edits In addition to our automatic evaluation, we perform a study of reactions to system-produced articles by the general public. To achieve this goal, we insert automatically created articles4 into Wikipedia itself and examine the feedback of Wikipedia editors. Selection of specific articles is constrained by the need to find topics which are currently of "stub" status that have enough information available on the Internet to construct a valid article. After a period of time, we analyzed the edits made to the articles to determine the overall editor reaction. In addition to the summary itself, we also include proper citations to the sources from which the material is extracted. Film Actors Search No Template Disjoint Full Model Oracle Diseases Search No Template Disjoint Full Model Oracle Precision 0. Information was removed in three cases for being irrelevant, one entire section and two smaller pieces. The most common changes were small edits to formatting and introduction of links to other Wikipedia articles in the body text. Since Wikipedia is a live resource, we do not repeat this procedure for our baseline systems. Adding articles from systems which have previously demonstrated poor quality would be improper, especially in Diseases. Therefore, we present this analysis as an additional observation rather than a rigorous technical study. By surpassing the Disjoint baseline, we demonstrate the benefits of joint classification. Furthermore, the high performance of both our full model and the Disjoint baseline relative to the other baselines shows the importance of structure-aware content selection. The remaining baselines have different flaws: Articles produced by the No Template baseline tend to focus on a single topic extensively at the expense of breadth, because there are no constraints to ensure diverse topic selection. This is expected; this baseline relies heavily on both the search engine and individual web pages. The search engine must correctly rank relevant pages, and the web pages must provide the important material first. Analysis of Human Edits the results of our observation of editing patterns are shown in Table 4. These articles have resided on Wikipedia for a period of time ranging from 5-11 months. All of them have been edited, and no articles were removed due to lack of quality. Moreover, ten automatically created articles have been promoted In this paper, we investigated an approach for creating a multi-paragraph overview article by selecting relevant material from the web and organizing it into a single coherent text. Moreover, our results demonstrate the benefits of structured classification, which outperforms independently trained topical classifiers. Overall, the results of our evaluation combined with our analysis of human edits confirm that the proposed method can effectively produce comprehensive overview articles. Diseases and American Film Actors exhibit fairly consistent article structures, which are successfully captured by a simple template creation process. However, with categories that exhibit structural variability, more sophisticated statistical approaches may be required to produce accurate templates. Any opinions, findings, conclusions, or recommendations expressed in this paper are those of the authors, and do not necessarily reflect the views of the funding organizations.

The child will also develop a lack of awareness and concern for her environment spasms from colonoscopy cheap 60caps shallaki amex, especially play activities muscle relaxant histamine release purchase shallaki 60 caps without prescription. Stage two of Rett syndrome has an onset around one to spasms left side under rib cage buy discount shallaki 60caps line three years of age and generally lasts from weeks to muscle relaxant with alcohol buy shallaki 60caps cheap months. Regression or loss of previously acquired skills most commonly characterizes this stage. The most predominant losses associated with Rett syndrome are the loss of purposeful hand use as well as speech. A decrease in social interaction and cognitive abilities also occurs during this period. The onset of stereotypic hand movements such as wringing, tapping, and mouthing begins during this stage and about 25% of them experience seizures. Although Rett syndrome is considered a disorder on the autism spectrum, it is often misdiagnosed as classical autism during this stage (Mazzocco et al. The third stage of Rett syndrome may occur somewhere during the ages of two to ten years old and may last from several months to years. During this stage, the girls tend have much more difficulty with motor planning leading to progressive ataxia and apraxia, which is often caused by spasticity and scoliosis. The cognitive functioning of the girls typically regresses to the range of severe mental retardation. However, the autistic tendencies are much less noticeable and social interaction seems to improve. Rett syndrome - 8 Finally, stage four of Rett syndrome usually occurs around age ten on and lasts for years. During this stage, persons affected typically lose much of their mobility due to increased spasticity, rigidity, scoliosis and progressive muscle wasting. Positively, seizure activity typically decreases dramatically and social skills, especially eye contact improves greatly during this stage. Unfortunately, there is very little expressive and receptive language present at this stage of the disorder (Harris et al. The age of onset, duration and severity of symptoms vary among each person affected with Rett syndrome. However, the symptoms listed above continue to be relatively consistent across most of the cases of Rett syndrome. Causation When Andreas Rett first discovered the collection of symptoms that was later identified as a specified disorder that received his name, he was uncertain of the cause of the disorder. According to Kerr (2002), Retts first thought was that the symptoms were associated with high levels of ammonia in the blood stream because he found this to be the case in some of the patients that he had seen. Many researchers believed from the beginning that the disorder was caused by a mutation on an X chromosome, but cases were so sporadic that it was almost impossible to perform linkage studies (Kerr, 2002). According to several studies, in all of the females identified as having classical Rett syndrome, about 80% of them have been identified as having a mutation in this gene (Kerr, 2002; Mount, Charman et al. According to Bird (2001) and Kerr (2002), it seems that there are genes that are being expressed in persons with Rett syndrome that should not be. Researchers continue to work to find exactly what genes those are and where they are located. Studies have also shown that the way that the X chromosome is inactive determines the severity of the disorder in each person (Kerr, 2002). The goal for researchers is to be able to identify what genes are being inaccurately expressed, where they are located and why it is occurring in specific cases of Rett syndrome. Recent research of Rett syndrome has lead to several answers, but also raised many new questions, which opens the door for several possible research areas. Determining a common cause of Rett syndrome will likely lead to more successful treatment options and possibly the discovery of a cure for this disorder in the future. Rett syndrome - 10 Treatment Implications At this time, there is no cure or precise treatment for Rett syndrome.

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In the event there is no detective assigned (County Court cases) muscle relaxant eperisone cheap 60 caps shallaki with amex, these images will be placed into evidence for later use in court muscle relaxant name brands cheap 60 caps shallaki otc. Department owned photographic/video equipment muscle relaxant use in elderly purchase 60caps shallaki free shipping, and all images produced thereby spasms on right side of stomach purchase 60caps shallaki otc, remain the sole property of the Denver Police Department. Officers are strictly prohibited from reproducing, displaying, or distributing these images (either digital or photographic) in any manner except for official purposes. Written approval of a command officer is required prior to using department images as training aids. The use of personal cameras/video by any officer acting in an official capacity at crime scenes, accidents, or natural disasters is expressly forbidden. Officers, on or off-duty, who gain access to any scene on the basis of their status as an officer, will be deemed to be acting in an official capacity. In the event personal equipment is used in an emergency to document perishable evidence, those images produced will be considered case evidence and governed by the provisions in the section above. All such images will be surrendered to the detective or investigative supervisor in charge of the case at the earliest possible convenience. Officers who have been trained in the use of the Axon Capture software may collect evidentiary digital photos and videos using this smart phone application. Officers will only use the photography and videography tools from within the application and will not store photos or videos on the phone otherwise. Officers will instruct all doctors, medical examiners, or paramedics who may be at the site of a homicide, not to disturb the scene or the body in any manner until all necessary photographs have been taken. Photographs may be disqualified as evidence if the original scene is altered in any way. Photographs will be taken at the scene of all homicides, suicides, and questionable deaths. Video documentation will be at the discretion of the officer in charge of the investigation. Photographs of victims of sexual assault, aggravated assault, child abuse, and other personal injury cases will be taken by Crime Lab personnel at the photo studio located at the Crime Lab. The investigating detective or supervisor must be present when photographs are taken for presentation in court. If the victim is female, a female city employee will be present at all times when photographs are taken. Personnel assigned to the Forensic Imaging Unit are responsible for specialized photography, such as micro, macro, and copy photography. All requests for photographic supplies and services will be processed through the director of the Forensic Imaging Unit. Cameras and recording media will be available to investigating officers when needed. Commanding officers may request that Forensic Imaging Unit personnel provide instruction in the operation of the photographic equipment for personnel under their command. Processing and printing of recording media will be done by the Forensic Imaging Unit. Photographs for court will be ordered on "Request for Photos" forms upon receipt of subpoenas. Only the officer assigned to the case will order photos and then only when the case is set for trial. Photographs taken at the scene of riots, disorders, protest demonstrations, marches, or similar incidents will be destroyed after the event if no illegal actions occurred. If illegal actions occurred, only those photographs that would be useful in illustrating the incident, identifying the participants in the illegal activity, or could be used in defending against a civil claim will be retained. Such photographs will be destroyed in the event no criminal or civil proceedings are filed. Photographs or video taken as a means of documenting police actions may be retained with authorization of the Chief of Police. The Evidence and Property Section allows for third party returns if the owner has signed a notarized release.

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Gene expression results could be confirmed by in situ hybridisations or protein activity assays spasms near sternum order shallaki 60 caps mastercard. Molecular pathologists are subgrouping cancers of tissues such as blood xanax muscle relaxant dosage buy 60 caps shallaki with mastercard, skin and breast spasms upper left quadrant order 60 caps shallaki amex, based on differential gene expression patterns spasms muscle twitching buy shallaki 60 caps with amex. The work was not conclusive, but never has progress in this field been so rapid when compared with the previous methods of gene identification. Microarray technology has also accelerated the understanding of the molecular events surrounding pulmonary fibrosis. Specifically, two distinct clusters of genes associated with inflammation and fibrosis have been identified in a disease where, for years, the pathogenesis and treatment have remained unknown (Katsuma et al. These quality metrics can be maximised by using, or fabricating, high-quality microarrays, and by optimising each step of the microarray process. From conception to conclusion it is important to bear in mind the original hypothesis. Having considered the complexity of the microarray experiment, the value obtained from a meticulously designed experiment should not be underestimated. As the number of high-quality gene expression studies increases, we hope that the literature will contain increasingly detailed information that will help interpret complex gene expression changes, and thus elucidate the mechanisms of disease. Crescenzi M and Giuliani A (2001) the main biological determinants of tumor line taxonomy elucidated by a principal component analysis of microarray data. Draghici S (2002) Statistical intelligence: effective analysis of high-density microarray data. Nadon R and Shoemaker J (2002) Statistical issues with microarrays: processing and analysis. Already in 1890, Hansemann observed that mitoses of epithelial tumour cells often were asymmetric. He considered the resulting imbalance between nucleus and cytoplasm to be the cause of malignant growth (Hansemann, 1890). However, it was Boveri who in 1914 hypothesized that cancer was the result of defects in the genetic material, which resides in the nucleus of somatic cells. It took until 1956 before the number of 46 human chromosomes was established (Tjio and Levan, 1956), but the great breakthrough came with the development of chromosome banding techniques in 1969, which made it possible to recognize all chromosomes individually. This development also allowed a characterisation of structural chromosomal rearrangements. The first of these was the Philadelphia chromosome observed in chronic myeloid leukaemia, now identified as the result of a translocation between chromosomes 9 and 22 (Rowley, 1973). The probe binds to homologous sequences within the chromosomes, and this can be visualised by fluorescence microscopy. This technique is very useful for investigating tumour series for specific chromosomal loci; however, for screening purposes of the whole genome it is inferior to other techniques. Solid tumours, which comprise around 95% of all human cancers, commonly exhibit many and complex chromosomal changes, but it is difficult to appreciate the meaning of recurrent and specific chromosomal changes against a background of a multitude of alterations (Jallepalli and Lengauer, 2001; Rowley, 2001). The observation that gross numerical and structural chromosome aberrations occur in high number in late stage tumours (invasive cancers), led some researchers to believe they are merely a side-effect of genetic instability driven by preceding mutations in oncogenes and tumour suppressor genes. This controversy remained for a long time mainly because data on chromosomal aberrations in early, pre-invasive tumours were scarce. Gains of whole chromosomes or whole chromosome arms are perhaps the most common early chromosomal changes in many tumour types (Ried et al. Such events may seem rather harmless, and indeed for many years the relevance of low-level gains (as opposed to high-level amplification) had not been recognised. However, it has recently been demonstrated that a single copy gain of a certain gene can have a strong effect on its expression levels (Redon et al. In general, the number of chromosomal aberrations increases with tumour progression, and non-random chromosome events have been found to correlate with specific tumour types and stages. These results show that changes at the chromosomal level cannot simply be set aside as mere side-effects of tumour progression. A gain or amplification in the tumour genome will be visualised by an excess of the green signal (and a fluorescence ratio >1. Using fluorescence microscopy and digital image processing, the ratio of the two is measured along the chromosomal axes. Images of the fluorescent signals are captured and the green-to-red signal ratios are digitally quantified for each chromosomal locus along the chromosomal axis.

References:

  • https://health.uconn.edu/cancer/wp-content/uploads/sites/180/2018/02/breast_cancer_resource_guide.pdf
  • https://pfe-pfizercom-d8-prod.s3.amazonaws.com/2020-11/C4591001_Clinical_Protocol_Nov2020.pdf
  • https://medicine.fiu.edu/about/departments/psychiatry-and-behavioral-health/_assets/mdcps-school-social-wkr-psychotropic-meds-presentation-posting-handouts-08.12.19.pdf